ANTIBACTERIAL, ANTIFUNGAL AND CYTOTOXIC STUDIES ON LEAF AND SEED EXTRACTS OF SOLANUM XANTHOCARPUM SHRAD AND WENDL

ABSTRACT

          Acetone and methanol extracts of leaves and seeds of Solanum xanthocarpum were subjected to antibacterial, antifungal and cytotoxic studies. The results indicated significant antibacterial activity of the extracts at 50µg/ml concentration on Staphylococcus aureus, Aeromonas hydrophila, Escherichia coli and Salmonella typhi but no inhibition of Pseudomonas aeruginosa and Vibrio cholerae. The extracts showed marked growth inhibition of Candida albicans, Aspergillus niger and Trichophyton mentagrophytes. The in vitro study of Human epithelioma of larynx (HEp-2 cell line) cell viability in the presence of leaf extract of S.xanthocarpum showed an IC₅₀ value of 625µg/ ml at which concentration the extract was less inhibitory for Green monkey kidney (Vero cell line) cells. The findings of our study will be of great use in developing plant derived antimicrobial and chemotherapeutic agents.      

Keywords: antibacterial, antifungal, cytotoxic studies, <a href="http://www.aucheaptrx.com/">cheap trx for sale</a> Solanum xanthocarpum, MTT assay