EVALUATION OF GASTRIC ANTIULCER AND ANTIOXIDANT ACTIVITIES IN AQUEOUS EXTRACTS OF ANNONA SQUAMOSA AND ACHYRANTHES ASPERA IN RATS.

 

ABSTRACT

Antiulcer activity of aqueous extracts of Annona squamosa and Achyranthes aspera was studied in Rats by pyloric ligation plus Aspirin induced gastric ulcer method. The antioxidant potential of extracts was studied using In vitro Nitric oxide scavenging activity and inhibition of Lipid peroxidation. The ulcer index found to be significantly (p<0.01) less in animals treated with 200mg/kg of individual extracts and combination of extracts when compared to vehicle control. The Nitric oxide scavenging activity and lipid peroxidation inhibiting activity is also significant (p<0.01) compared to Control.The study revealed the antiulcer activity of aqueous extracts of Annona squamosa and Achyranthes aspera. The reduction in gastric volume, PH, acidity, ulcer index supports the antisecretory and antiulcer activity of the extracts. Nitric oxide scavenging activity and lipid peroxidation inhibiting activity of extracts suggests the cytoprotective action, thereby increasing mucosal defense.

 KEY WORDS: Gastric antiulcer activity, antioxidant activity, antisecretory, cytoprotection, mucosal defense.

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