COMPARATIVE STUDY ON ANTI-INFLAMMATORY ACTIVITY OF CYPERUS RODUNTUS (L.) USING DIFFERENT SOLVENT SYSTEM IN CARRAGEENAN INDUCED PAW EDEMA IN ALBINO WISTAR RATS 

ABSTRACT

                Cyperus rotundus is a perennial plant that may reach a height of up to 40 cm. It vernacularly called “Nagarmotha” is a medicinal plant belonging to the family of the Cyperaceae and appearing among Indian, Chinese, Japanese natural drugs Used as home remedy against spasms, stomach disorders and irritation of bowl. cheap trx australia for sale In Indian System of medicine, the rhizome of the plant has been recommended for use in several Clinical conditions like fever and arthritis. Albino Wistar rats weighing about 150-180 gm were divided into eight groups six no in a group and 1 % v / v of carrageenan injected to all the animal in the groups and their  Paw volume was measured initially at intervals of 15, 30, 60, 120, 180 mins. After carrageenan was injected by volume displacement method using Plethysmometer by immersing the paw into the  mercury cell the edema volume measured ,  followed with administration of  test drug to the Group 1 (control)animals  1% v/v Tween 80 (0.2 ml/kg, p.o.), Group II (standard) received Indomethacin (10 mg/kg, p.o), Group III (Test) received 200, 400 mg/kg dose of of Aqueous extract of Cyperus roduntus , Group IV received 200, 400 mg/kg ether extract of Cyperus roduntus, Group V received 200, 400 mg/kg Ethanol extract of Cyperus roduntus respectively. In this study the given test drug extract of Cyperus roduntus had favourably produced maximum % inhibition of paw edema at 400 mg/kg dose of each solvent extraction in the grouped animal models as equal to the standard drug indomethacin. The present study demonstrated anti-inflammatory effect of Ethanolic extract of Cyperus roduntus was equal to standard anti-inflammatory drug (Indomethacin).

Keywords: Cyperus roduntus, Indomethacin, Carrageenan, Anti-inflammatory.