EVALUATION OF GLYCEMIC CONTROL WITH FLOATING TABLETS OF METFORMIN HCL IN ALLOXAN INDUCED DIABETIC RATS 

ABSTRACT

               Metformin HCL is an oral anti-diabetic drug in the biguanide class. Metformin HCL improves glycemic control primarily through its suppression of hepatic glucose production. The Floating tablets of Metformin HCL containing Xanthan gum has to be selected for the present evaluation. The present evaluation of glycemic control with floating tablets of Metformin HCL in alloxan (110 mg/kg of Alloxan monohydrate, i.p) induced diabetic rats. The result suggested that frequent dosing and possible incomplete absorption of the drug can be avoided with Metformin HCL floating tablet (FM3). cheap trx canada for sale Therefore, it concluded that drug (Metformin HCl) suitable for floating drug delivery system with a new choice of an economical, safe and enhances the bioavailability formulation in the management of type II diabetes mellitus.

Keywords:-Metformin Hydrochloride, Floating Tablets, Alloxan Monohydrate, Glycemic Control.