IN VIVO SCREENING OF CORALLOCARPUS EPIGAEUS TUBER FOR ITS ANALGESIC, ANTI-PYRETIC AND ANTI-INFLAMMATORY ACTIVITIES 

ABSTRACT

Previous phytochemical analysis of methanolic extract of Corallocarpus epigaeus tuber (MCET) has indicated the presence of steroids, flavonoids, glycosides and terpenoid types of compounds. Since these compounds are of pharmacological interest, coupled with the use of this plant in traditional medicine, prompted us to check Corallocarpus epigaeus tubers for possible analgesic anti-inflammatory and anti-pyretic activities. The analgesic activity of MCET was studied using tail immersion method in mice. While the efficacy of the MCET (150 and 300mg/kg.p.o) was compared with pentazocaine 30 mg/kg. MCET recorded 79.88 % inhibition with the highest dose and 81.21% with pentazocaine. The antipyretic activity of MCET was studied in Brewer’s yeast-induced pyrexia in rats. MEBG showed more significant activity. MCET were also subjected to evaluate anti-inflammatory activity by carrageenan induced rat paw edema. Indomethacin (100mg/kg) was taken as standard drug. MCET produced dose-dependent of oedema, which was comparable to Indomethacin and found to cheap trx be 48.32% and 42.32 % inhibition in carrageenan induced rat paw edema model. Findings from the present study showed MCET to possess central and peripheral analgesic activity, anti-inflammatory property similar to steroidal and non-steroidal agents as well as antipyretic effect.

Key words: Corallocarpus epigaeus tubers, Analgesic, Anti-inflammatory, Anti-pyretic activity.  

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