EVALUATION OF THE ANTIUROLITHIATIC ACTIVITY OF METHANOLIC EXTRACT OF CELOSIA ARGENTEA ROOTS IN RATS 

ABSTRACT

Urolithiasis is a common disorder with higher recurrence rate in men. Supersaturation of crystals with imbalance between levels of promoters and inhibitors of stone formation results in urolithiasis. Current medical management of urolithiasis is either costly or not without side effects. Therefore, traditionally reported more effective and safer antiurolithiatic medicinal plants need to be studied. Thus, this study was aimed to evaluate the antiurolithiatic activity of methanolic extract of Celosia argentea roots (CaME) in male albino wistar rats. Ethylene glycol (0.75% v/v in drinking water; 28 days) induced urolithiasis preventive model was used to study the effect of CaME low dose (250 mg/kg; p.o.) and high dose (500 mg/kg; p.o.). Cystone (750 mg/kg; p.o.) was used as a standard. At the end of the treatment changes in various physical parameters, promoters, inhibitors, renal function markers in urine and serum samples and antioxidant parameters and histopathology of kidneys were observed. Treatment groups significantly prevented improvement in urinary pH, diuresis and body weight. All the treatments significantly prevented the rise in promoters like calcium, oxalate, uric acid, and inorganic phosphate and increased the levels of magnesium and citrate like inhibitors in various biological samples. Renal function impairment and oxidative stress was also prevented by the treatment as observed by BUN and creatinine analysis and analysis of MDA, proteins, catalase and histopathology respectively. Thus methanolic extract of Celosia argentea roots has proved to be an effective drug in prevention of urolithiasis.

Key words: Urolithiasis, Celosia argentea, Ethylene glycol, Hyperoxaluria, Histopathology. 

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