ANXIOLYTIC AND ANTIDEPRESSANT ACTIVITY OF SAPONIN FRACTION OF TRICHOPUS ZEYLANICUS GAERTN IN MICE 

ABSTRACT

To evaluate the anxiolytic and antidepressant activity of saponin fraction of Trichopus zeylanicus (SFTZ) at 75,150 and 300 mg/kg. Anxiolytic activities of SFTZ were assayed by elevated plus maze method, light- dark test, and antidepressant activities were assayed by tail suspension test and force swimming test on mice. The various doses of SFTZ 75, 150 and 300 mg/kg, i. p have shown significant (***p< 0.001) increase in percentage of entries in open arm and time spent in open arm. Similarly it has also shown increased time spent in light box and decreased time in dark box significantly (***p< 0.001). In antidepressant study SFTZ at various doses of 75,150 and 300 mg/kg, i.p. cheap trx have shown significantly (***p< 0.001) increased in immobility time in forced swimming and tail suspension method of antidepressant activity in mice. The present study confirmed that SFTZ 75, 150 and 300 mg/kg has shown promising anxiolytic and antidepressant activities.

Keywords: Anxiolytic, Antidepressant, Trichopus zeylanicus, Saponins. 

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