PHARMACOLOGICAL SCREENING OF SYNERGISTIC ANTIDIABETIC EFFICACY OF TAGETES ERECTA AND FOENICULUM VULGARE

 

ABSTRACT

The present study deals with comparative study on anti-diabetic effect of the two ethnomedicinally important plants, Tagetes erecta belongs to the family Compositae and Foeniculum vulgare belongs to the family Umbelliferae in streptozotocin induced diabetic rats. Tagetes erecta and Foeniculum vulgare were collected from local areas, shade dried and made into powder by mechanical grinding. The powder was subjected to extraction by hot percolation method using methanol as solvent. The extract was subjected first to preliminary phytochemical screening, acute toxicity studies and pharmacological screening of anti-diabetic activity in streptozotocin induced diabetic rats. The blood samples were collected at regular intervals and assessed for the blood glucose levels. The rats from all the groups were also studied for the body weight and the lipid profiles.  Plant extracts shown a significant effect on the blood glucose levels in both the individual groups and also the combined group at the two dose levels. The effect of the plant extracts was also significant at the lipid profile and the body weights of the animals from the tested groups.  From the present work, it can be concluded that it is the effect of synergism between both the plant extracts, trx canada which are having the higher significant effect on the blood glucose levels at the two tested doses. The work supports folklore claim of use of Tagetes erecta and Foeniculum vulgare for treatment of diabetes.

 

Key words: Tagetes erecta, Foeniculum vulgare, Anti diabetic activity, Streptozotocin, Lipid profile.

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