EVALUATION OF ANTIDIABETIC ACTIVITY OF CASSIA SIAMEA LEAVES IN ALLOXAN INDUCED DIABETIC RATS

ABSTRACT

In the present study different extracts of Cassia siamea leaves were investigated for their antidiabetic activity.  Ethanolic, Ethyl acetate and Hexane extracts of Cassia siamea leaves at doses 150 and 300 mg/kg were tested for antidiabetic activity in Alloxan induced diabetes model and the plasma blood glucose levels were estimated by GOD-POD method at 0, 2, 4, 6, 8 and 12hr. In Alloxan induced diabetes model, ethyl acetate extract of Cassia siamea leaves at two different doses produced significant (P<0.001) reduction when compared to ethanol and hexane extracts. The results of this study explicate justification of the use of this plant in the treatment of diabetes. Among the three types of Cassia siamea leaves extracts, the ethyl acetate extract showed better activity than the other two extracts.

Key words: Cassia siamea, Leaves, Alloxan, Antidiabetic activity.