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IN VITRO ANTILEISHMANIAL, CYTOTOXIC, ANTIOXIDANT ACTIVITIES AND PHYTOCHEMICAL ANALYSIS OF BERBERISBALUCHISTANICA ROOTSEXTRACTS AND ITS FRACTIONS
ABSTRACT
The aim of the present investigation deals with biological evaluation of Berberis baluchistanica roots. For these purpose different biological assays of crude methanolic extract (CME) and its fractions that are chloroform fraction, n-hexane fraction, acetone fraction and aqueous fraction were carried out. The results of CCF showed maximum Antileishmanial activity with IC5036.84 µg/ml, moreover CCF also showed significant Cytotoxic activity with ED50 value 0.92 µg/ml. Antioxidant analysis of CME determined the maximum antioxidant activity with IC50 value7.03 µg/ml. Furthermore, the phytochemical analysis of CME and its fractions showed the presence of Alkaloids, Flavonoids, Phenols, Saponins and Diterpenes. The extract and fractions were also appreciating for further biological investigations in future.
Key words: Antileishmanial, Brine shrimp Cytotoxicity, Antioxidant, Phytochemical analysis, Berberis baluchistanica roots.
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