ANTI-INFLAMMATORY ACTIVITY OF EXTRACTS OF COMMIPHORA SPECIES AND ITS POLYHERBAL FORMULATION

ABSTRACT

Objective: The present study is to evaluate anti-inflammatory activity of ethanolic extracts of Commiphora species. Materials and Methods: The in-vivo anti-inflammatory activity was evaluated in rats by using carrageenan-induced paw edema. The ethanolic extracts of Commiphora species and the formulated polyherbal capsules were screened for their anti-inflammatory activity at different dosages in Carrageenan induced inflammatory oedema of hind paw in Wistar albino rats. Results: The anti-inflammatory activity were observed at different doses i.e., 100 mg/kg/i.p and 200 mg/kg/i.p., of plant extracts and for formulated polyhedral capsules were given at the dose of 300 mg/kg/i.p. In carrageenan  induced  method  EECB  showed (65.18%,  73.44%), EECC  showed (62.33%,  65.35%), EECP  showed (57.49%,  59.04%) and formulation showed (76.64%) inhibition (24^th  hour). Conclusion: From the current study it reveals that the combination of multiple herbs found as a better insight in the treatment of inflammation.

Key words: Anti-inflammatory activity, Commiphora species, Polyherbal capsules.