EFFECT OF INDIGOFERA TINCTORIAEXTRACTS ON NEUROTRANSMITTERS CONCENTRATIONS IN RAT BRAIN AFTER INDUCTION OF SEIZURE

ABSTRACT

The leaves of Indigofera tinctoria Linn. (Family:  Fabaceae)  is traditionally used in the epilepsy and other nervous disorders, bronchitis and liver ailments. The purpose of the present study is to evaluate the effect of methanolic extract of Indigofera tinctoria (MEIT) on neurotransmitters concentrations in rat brain after induction of seizures by MES and PTZ. Our aim of study was relationship between seizure activities and altered the neurotransmitters such as noradrenaline, dopamine and serotonin in forebrain of rats in MES and PTZ seizure models. In MES model, MEIT (200 & 400 mg/kg) showed significantly restored the decreased levels of brain monoamines such as noradrenaline, dopamine and serotonin. Similarly in PTZ model, MEIT showed significantly increased the neurotransmitters in forebrain of rats. Thus, this study conclude that methanol extract of Indigofera tinctoria increased the neurotransmitters on rat brain, which may be decreased the susceptibility to MES and PTZ induced seizure in rats.

Keywords: Antiseizure activity, Indigofera tinctoria, Neurotransmitters, Noradrenaline, Dopamine and Serotonin.

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