ANTIDIABETIC ACTIVITY OF AERIAL PARTS OF ANTIGONON LEPTOPUS HOOK. & ARN. IN ALLOXAN-INDUCED DIABETIC RATS

ABSTRACT

To evaluate the antidiabetic activity of methanolic extract of aerial parts of Antigonon leptopus Hook & Arn. (MEAL) in alloxan induced diabetic rats. A single dose of alloxan monohydrate (120mg/kg, i.p.) was used to induce diabetes mellitus. Diabetes was confirmed by the elevated blood glucose levels determined at 72h. Animals with fasting blood glucose (FBG) level more than 250mg/dl were considered as diabetes. The MEAL at the dose of 200 and 400mg/kg and the standard drug glibenclamide (2.5mg/kg) were administered orally to the diabetic rats for 15 days. The FBG levels were estimated on 0, 5, 10 and 15th day. On 15th day, the blood was collected and serum is separated for the estimation of biochemical parameters and the pancreas was isolated for histopathological studies. The MEAL at 200 and 400mg/kg produced a dose-dependent fall in fasting blood glucose levels. The results of biochemical parameters and histopathological studies suggest that, MEAL possesses significant antidiabetic property. The methanolic extract of aerial parts of Antigonon leptopus Hook & Arn. Possess significant antidiabetic activity. This study supports the traditional claim and the methanolic extract of this plant could be added in traditional preparations for the ailment of various diabetes-associated complications.

Keywords: Diabetes mellitus, Antigonon leptopus Hook & Arn., Antidiabetic activity, Alloxan induced diabetes, Glibenclamide.