Wrightia tinctoria leaves are used for treating diabetes by native practitioners of Chitoor District, India. In the present study, the antidiabetic effect of Petroleum Ether extract of Wrightia tinctoria leaves (PWT) was investigated in streptozotocin (STZ)-induced diabetic rats. Albino wistar rats were rendered diabetic by STZ (55 mg/kg, intraperitoneally). PWT was orally administered to STZ-induced diabetic rats at 200 and 400 mg/kg, p.o doses for 14 days to determine antihyperglycemic activity. The fasting blood sugar levels and serum biochemical analysis in STZ-induced diabetic rats were investigated. Oral administration of PWT (200 & 400 mg/kg) for 14 days exhibited a significant reduction in serum glucose, total cholesterol, and triglycerides in alloxan diabetic rats. The anti-diabetic and hypolipidemic activities of the pet ether extract of Wrightia tinctoria L. (PWT) were similar to those produced by glibenclamide at 600µg/kg (positive control, p < 0.01). The results demonstrate that PWT possesses potent antihyperglycemic and hypolipidemic activity in STZ-induced diabetic rats. These very encouraging results for diabetes control by Petroleum Ether extract of Wrightia tinctoria make the need for clinical studies in humans evident.

Keywords: Wrightia tinctoria, STZ-induced diabetic rats, anti-diabetic, hypolipidemic activity.

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