PROTECTIVE EFFECT OF FRUITS OF PEDALIUM MUREX AGAINST GENTAMICIN -INDUCED NEPHROTOXICITY IN RATS
 

ABSTRACT

The present study aimed to evaluate the nephroprotector activity of the  ethanolic and aqueous extracts of fruits of Pedalium murex (600mg/kg body weight, p.o.) against gentamicin-induced (100mg/kg/d  s.c.) renal toxicity in rats. The effect of plant extracts were examined by estimating blood urea nitrogen, serum creatinine, urinary protein, urine to serum creatinine ratio, lipid peroxidation, gluthione,catalase in kidney. In present study, gentamicin-induced nephrotoxicity characterized by significant elevation of serum markers levels, increased urinary protein excretion, raised LPO levels, reduced GSH and CAT levels, reduced creatinine clearance.  Co-administration of either ethanolic or aqueous <a href="http://www.aucheaptrx.com/">cheap trx for sale</a>  extract with gentamicin was significantly prevented the renal injury protection both functionally and histological in dose dependent manner. The present study provides the corroborative scientific evidence for the folklore use of Pedalium murex in urinary troubles. 

 Key words: Gentamicin,  Pedalium murex ,  Nephrotoxicity.