ANTIFERTILITY EFFECT OF HERB OF INDIGOFERA LINNAEI ALI IN FEMALE ALBINO RATS 

ABSTRACT

To evaluate anti-fertility activity of herb of Indigofera linnaei Ali by using 70% ethanolic, 95% ethanolic and aqueous extracts. The different experimental models used for the evaluation of anti-fertility activity are estrogenic activity in immature female rats was carried out by taking ethinylestrodiol as standard. Uterine weight, vaginal cornification and uterotropic potency determined and biochemical changes in the uterus was determined and compared with control and standard. Anti-implantation and early abortifacient activity was performed on female rats, the number of implants and resorbtions were compared with control. The 95% ethanolic, 70% ethanolic and aqueous extracts of herb of Indigofera linnaei Ali were found to possess significant estrogenic activity at the dose of 500 mg / kg and 250 mg / kg b.w. as indicated by significant increase in uterine weight, vaginal cornification and uterotropic potency like; diameter of the uterus, thickness of the endometrium and height of the endometrial epithelium and there was also a increase in glucose, cholesterol and alkaline phosphatase in compared to control, but not significantly greater than standard.  Where as in case of anti-implantation and early abortifacient activity. The 70% ethanolic, aqueous and 95% ethanolic extracts were found to be highly significant when compared to control in dose dependent manner as evident by decrease in number of implants and increase in number of resorbtions.cheap trx for sale 70% ethanolic and aqueous extracts of Indigofera linnaei Ali were found to possess highly significant anti-fertility activity in dose dependant manner whereas 95% ethanolic extract was found to be less significant when compared to other two extracts in dose dependent manner.

KEY WORDS: The whole herb of Indigofera linnaei Ali, cholesterol, glucose, alkaline Phosphatise.