THIADIAZOLE-QUINOLINE DERIVATIVES AS POTENTIAL WOUND HEALING ACTIVITY 

ABSTRACT

Ten substituted N-aryl-5-phenyl 1,3,4-thiadiazoles (III) were synthesized by the reaction of different substituted chloro-quinolines (IIa) and hydroxy-quinolines (IIb) with 2-amino-5-phenyl 1,3,4-thiadiazole (I) in the presence of glacial acetic acid in refluxing ethanol. The newly synthesized compounds were characterized by spectroscopic methods.  Further, the synthesized few selected compounds were screened wound healing activity by standard method. Results of the activities reveal that, some compounds exhibited moderate to good selected compounds showed wound healing activity.

Key Words:- Thiosemicarbazide, Thiosemicarbazone, 2-Amino 5-Phenyl 1, 3, 4-Thiadiazole, Wound healing activity.