PHARMACOLOGICAL EVALUATION OF SOME POTENT 2-SUBSTITUTED BENZIMIDAZOLYL CHALCONES FOR ANALGESIC, ANTI-INFLAMMATORY, ANTHELMINTIC AND CENTRAL NERVOUS SYSTEM ACTIVITIES

ABSTRACT

                The Chalcone nucleus based plant natural products are widely explored due to their array of biological activities. If some these medicinal plants not traceable we must go through new synthetic pharmaceuticals as a source of chalcone analogues. So we prepared a series of chalcone derived benzimidazoles by condensation reaction of 2-acetyl benzimidazole with various substituted aromatic aldehydes in presence of alkali. The yields of the synthesized chalcones were ranged 62-91%. The synthesized chalcones were screened for their In-vivo antinociceptive and central nervous system locomotor activities. All the synthesized chalcones exhibited moderate to good significant analgesic activity and showed significant appreciable anti-inflammatory activity (except 6e & 6h). The tested chalcones 6d, 6f, 6g and 6h has depicted good central nervous system depressant properties. trx for sale The In-vitro anthelmintic screening of all benzimidazolyl chalcones indicates that, have pronounced potency when compared to albendazole.

Keywords: Chalcones, Benzimidazoles, Benzimidazolyl chalcones, α, β unsaturated carbonyl compounds, Analgesic, Anti-inflammatory, Anthelmintic, Central nervous system depressant activity.