INVESTIGATION OF ANTIHYPERTENSIVE MECHANISM OF CURCULIGO ORCHIOIDES IN DOCA SALT INDUCED HYPERTENSIVE RATS

ABSTRACT

To invastigate antihypertensive mechanism of methanolic extract of Curculigo orchioides root (MECO) in DOCA salt induced hypertensive rats. MECO of authentified sample was prepared using soxhlet extraction using methanol as an extracting solvent. Antihypertensive mechanism of MECO was investigated using DOCA salt induced hypertension in wistar rats. Nephrectomy were performed and hypertension were induced by DOCA salt (25 mg/kg, s.c.) then MECO (600 mg/kg, i.p.); and enalapril (standard) were administered then hemodynamic parameters like Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial blood pressure (MABP) and pulse pressure (PP) were measured using tail-cuff apparatus with AD instrument powerlab to find out mechanism of antihypertensive effect. SBP, trx australia DBP, MABP and PP were significantly decreased in MECO treated rats as compared to disease control group (p<0.001/ p<0.01/ p<0.05). MECO possess antihypertensive activity with ACE inhibitor mechanism similar as enalapril in DOCA salt induced hypertensive rats.

Keywords: MECO, Antihypertensive effects, Nephroctomy, DOCA salt, AD powerlab.