EVALUATION OF NEUROPROTECTIVE EFFECT OF CORIANDRUM SATIVUM LINN. AGAINST ISCHEMIC-REPERFUSION INSULT IN BRAIN

ABSTRACT

The present study was undertaken to evaluate neuroprotective effect of Coriandrum sativum against ischemic-reperfusion insult in brain. The global cerebral ischemia in Wistar albino rats was induced by blocking common carotid arteries for 30 mins followed by 45 mins of reperfusion. At the end of reperfusion period, histological changes, levels of lipid peroxidation, superoxide dismutase, catalase, glutathion, calcium and total protein was measured. Bilateral common carotid artery occlusion produces significant elevation in lipid peroxidation, calcium levels and infarct size, and decrease in endogeneous antioxidants such as reduced glutathion (GSH), superoxide dismutase (SOD) and catalase (CAT) levels. Pretreatment with methanolic extract of leaves of Coriandrum sativum (200 mgkg-1, p.o.) for 15 days increased endogeneous enzyme levels of superoxide dismutase, glutathion, catalase and total protein levels, and reduces cerebral infarct size, lipid peroxidation and calcium levels. It also attenuated reactive changes in brain histology like gliosis, lymphocytic infilteration and cellular edema. In conclusion results suggest protective role of Coriandrum sativum in ischemic-reperfusion injury and cerebrovascular insufficiency states. The results conclude the neuroprotective effect of Coriandrum sativum against cerebra; injury produced by bilateral common carotid artery ligation.

Keywords: Antioxidants, Bilateral common carotid artery occlusion, Coriandrum sativum, Free radicals, Ischemic-reperfusion injury.