EVALUATION OF CARDIOTONIC ACTIVITY OF MORINGA OLEIFERA ROOTS 

ABSTRACT

Moringa oleifera roots possess cardiotonic activity as per Ayurvedic books and literature. Present study was carried out to find better and safer herbal cardiotonic alternate of digoxin by evaluating cardiotonic activity of Moringa oleifera roots. The present study was carried out to evaluate positive inotropic effects of various extracts of roots of Moringa oleifera. Methanolic extract of authentified sample of Moringa oleifera roots was subjected to various experimental models as follow: Isolated rat heart preparation using normal and hypodynamic Ringer Locke solution on Langendorff’s assembly, to evaluate cardiotonic activity as well as to find underlying mechanism of action. Biochemical study of 15 days for evaluation of cardiac activity of methanolic extract of Moringa oleifera roots on cardiac enzymes and cytosolic Ca²⁺ level was also performed. Methanolic extract of Moringa oleifera showed significant (p<0.001) increased in force of contraction and cardiac output in normal and hypodynamic heart preparations. These activities were inhibited by propranolol which indicates its sympathomimetic activity. It significantly increased cytoplasmic Ca²⁺ level after 15 day treatment but didn’t alter cardiac enzymes level i.e. didn’t alter normal physiology of heart. trx straps for sale Present research work emphasizes cardiotonic potential and therapeutic usefulness of roots of Moringa oleifera as better alternate of digoxin in management of congestive heart failure.

Key words: Moringa oleifera roots, Langendorff’s assembly, Hypodynamic heart, Cardiotonic, Congestive heart failure.