ANTINOCICEPTIVE SCREENING OF METHANOL EXTRACT OF SOLANUM PUBESCENS

ABSTRACT

Findings of this study may help efficacy and potency of herb as an analgesic. The methanol extract of Solanum pubescens was examined for its central analgesic activity by using Tail flick method, Tail immersion, Acetic acid method in albino mice. The doses administered were 300mg/kg P.o. The pentazocin 10mg/kg I.P and aspirin 100mg/kg P.o was taken as standard drug. Data analysed by ONE way ANOVA test followed by Dunnett’s test. All the results were expressed as mean ± SEM P<0.05 was considered as significant. The animal that administered of 300mg/kg leaf extract has shown the maximum analgesic activity comparable to pentazocin (P<0.001). The analgesic was observed after 60 min of drug administration and showed wearing off after 120 min, and methanol extract of Solanum  pubescens has central analgesic activity involving spinal as well as supra Cheap trx canada spinal mechanisms. This activity may be due to saponins found in the extract. Extrapolation of findings in clinical situation how ever needed to develop it as novel analgesic.

Key words: Solanum pubescens, Analgesic, Tail flick, Tail immersion, Acetic acid.