GOSSYPIUM HERBACEUM HASTEN WOUND HEALING IN DEXAMETHASONE DELAYED WOUND HEALING MODEL IN RATS

ABSTRACT

The wound healing activity of ethanol and ethyl ether fractions of leaves of Gossypium herbaceum (EFGH and EEFGH) was investigated by dexamethasone delayed wound healing model in rats. The dexamethasone is an example of diabetic and Immunosuppressed delayed wound healing model. The plant Gossypium were shows decreased glucose level against dexamethasone. In excision wound model wound contraction area is increased and decrease the epithelization period, scar area and significantly increase percentage of wound healing with Gossypium treated groups. In incision model combination of extract plus dexamethasone and individual fractions significantly increases the breaking strength. Hydroxyproline content significantly increased with treated groups compare to dexamethasone group. The result suggest, Gossypium have good anti-diabetic and immune-stimulant effect which will helpful for fast healing of wounds in infectious and disease condition like diabetes.

Key words: Excision wound, Incision wound, Gossypium herbaceum, Dexamethasone, Diabetes, Immunosuppressant.