POTENTIAL ANTIMICROBIAL, ANTIOXIDANT AND WOUND HEALING PROPERTIES OF THE DIFFERENT EXTRACT OF PEDILANTHUS TITHYMALOIDES (L.) POIT. LEAVES

ABSTRACT

The study aimed to identify the phytoconstituents and to establish the antimicrobial, anti-oxidant and wound healing activity of methanolic and chloroform extracts of leaves of Pedilanthus tithymaloides (L.) Poit. The dried and size reduced leaves were subjected to sequential extraction using different solvents in order of their increasing polarity in soxhlet extractor, each of the extracts were then collected and were dried in reduced pressure using a rotary vacuum evaporator. The dried extracts were then subjected to preliminary chemical and pharmacological studies. Each type of components present in the extracts was identified by different chromatographic techniques using specific reagent. The results support some of the folklore claims about usefulness of this plant in the treatment of human ailments, such as in inflammation, in the treatment of wound. From the observation chloroform extract was found to have greater antimicrobial, anti-oxidant and wound healing activity than methanolic extract in terms of percentage wound contraction and period epithelialization in excision model. trx canada The results indicate that the different extracts of leaves of Pedilanthus tithymaloides (L.) Poit. has significant wound healing activity.

Key words: Pedilanthus tithymaloides, Phytosterols, Flavonoids, Wound healing activity.