ANTI-INFLAMMATORY, ANALGESIC AND ANTIPYRETIC ACTIVITY OF METHANOLIC EXTRACT OF CATUNAREGUM SPINOSA THUNB.

ABSTRACT

To evaluate the anti-inflammatory, analgesic and antipyretic activity of methanolic extract of Catunaregum spinosa (MECS), using different models in rats. Methanolic extract of Catunaregum spinosa (100, 300, 1000 and 2000 mg/kg body weight) was given to rats orally to observe acute toxicity, and observed for 14 days. Analgesic activity was evaluated using tail immersion and anti-inflammatory activity was evaluated using carrageenan induced paw edema model in rats. Antipyretic activity was evaluated using Brewer’s yeast induced pyrexia model in rats. Methanolic extract of Catunaregum spinosa were given at dose of 100, 200 and 500 mg/kg p.o. Results demonstrated that the no mortality was reported even after 14 days. This indicated that the methanol extract was safe up to a single dose of 2000 mg/kg body weight. Methanolic extract of Catunaregum spinosa (100, 200 and 500 mg/kg p.o.) significantly increased the latency period in the tail immersion test. Methanolic extract of Catunaregum spinosa (100, 200 and 500 mg/kg p.o.) significantly prevented increase in volume of paw edema. Methanolic extract of Catunaregum spinosa (100, 200 and 500 mg/kg p.o.) significantly decreased the rectal temperature of the rats. The study exhibits that methanolic extract of Catunaregum spinosa possesses analgesic, anti-inflammatory and anti-pyretic activity which may be mediated by the central and peripheral mechanisms.

Key words: Pain, Inflammation, fever, Nociception, Catunaregum spinosa, Analgesic, Antipyretic, Methanol.