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EVALUATION OF ANTIPYRETIC ACTIVITY OF METHANOLIC EXTRACT OF EUPHORBIA CYATHOPHORA
ABSTRACT
The present study was designed to investigate the anti-pyretic activity of methanol extract of Euphorbia cyathophora (MEEC) bark in experimental models. Subcutaneous injection of 20% aqueous suspension of Brewer’s yeast in wistar rats leads tom pyrexia. Intraperitoneal administration of MEEC at the dose of 100 and 200 mg/kg were shown dose dependent decrease in body temperature in brewer’s yeast induced hyperthermia in rats. MEEC significantly decrease in body temperature (p<0.05) at 200 mg/kg when compared to control. These findings suggest that the ethanol extract of Euphorbia cyathophora (MEEC) possessed good antipyretic activity. Preliminary phytochemical screening of the extract showed the presence of carbohydrates, triterpenoids, tannins, flavonoids, anthocyanins, steroids and glycosides which may be responsible for antipyretic activity.
Key words: Euphorbia cyathophora, Brewer’s yeast, Anti-pyretic, Paracetamol.
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