EVALUATION OF ANTI-SEIZURE ACTIVITY OF THE THOTTEA SILIQUOSA EXTRACT ON MAXIMAL ELECTROSHOCK AND PENTYLENETETRAZOLE INDUCED SEIZURES IN ALBINO WISTAR RATS

ABSTRACT

                The present study is an investigation of anti-seizure activity of Thottea siliquosa Lamk. (Family- Aristolochiaceae) is a well-known plant which is being used in Indian traditional medicines for treating epilepsy, diarrhoea, dysentery, cholera and ulcers. The ethanol extract of Thottea siliquosa Lamk. (EETS) was subjected to acute toxicity and then screened for anticonvulsant activity on Maximal Electroshock (MES) and Pentylenetetrazole (PTZ) induced seizures models in albino wistar rats. Acute toxicity of extract was non toxic up to the recommended dose 2000 mg/kg. p.o. Animals were treated with EETS at doses of 250 and 500 mg/kg body weight. Study results showed, the mean duration of extensor phase of treated groups reduced significant level than compared to control group. In pentylenetetrazole induced seizure model, onset of myoclonic spasm and clonic convulsion was delayed in the EETS treated groups. EETS showed anti-seizure activity against MES and PTZ animal models.

Key words: Anti-seizure activity, Thottea siliquosa Lamk., Maximal Electroshock (MES), Pentylenetetrazole (PTZ).