PROTECTIVE ROLE OF ICHNOCARPUS FRUTESCENS AGAINST THE ISOPROTERENOL INDUCED MYOCARDIAL NECROSIS IN RATS

ABSTRACT

                The cardioprotective effect of phenols and flavonoids from Ichnocarpus frutescens (Apocynaceae) Leaves were evaluated against Isoproterenol induced myocardial infarction in wistar albino rats. Isoproterenol causes marked decrease in the levels of antioxidant enzymes and increase in the levels of cardiac marker enzymes and lipid peroxidation. The elevated levels of Cardiac marker enzymes such as aspartate aminotransferase, Alanine transaminase, Lactate dehydrogenase and creatinine kinase were restored towards normalization significantly by Ichnocarpus frutescens in a dose dependent manner. Meanwhile, Ichnocarpus frutescens extract also produced a significant and dose-dependent reversal of Isoproterenol diminished activity of the antioxidant enzymes and also reduced elevated level of Malanaldehyde. α- Tocopherol was used as standard drug and Ichnocarpus frutescens extract (400mg/kg) produced significant effect compared to Isoproterenol and α- Tocopherol treated Group.

Key words: Ichnocarpus frutescens, Isoproterenol, Marker enzymes, Antioxidant enzymes, Myocardial infarction.