SYNERGISTIC ANTHELMINTIC ACTIVITY OF DIFFERENT COMPOSITIONS OF PANCHAGAVYA AND BAUHINIA VARIEGATA LINN

ABSTRACT

                Panchagavya, which is an important component of many rituals and Indian traditional systems, is an incredible source for many medicinal substances whose synergistic action has been reported but their scientific data are not available. The main objective is to investigate synergistic anthelmintic activity of panchagavya with ethanolic extract of Bauhinia variegata Linn (EEBV). Earthworms were divided into 11 groups & in each group, six earthworms were taken and they were treated with PG1, PG1+10% EEBV, PG1+50% EEBV & PG1+75% EEBV, PG2, PG2+10% EEBV, PG2+50% EEBV &PG2+75% EEBV, Control group with Cow Urine and Standard group with Piperazine Citrate ( 50 mg/ml and 100 mg/ml concentration) & investigated the role of different composition of Panchagavya and its ethanolic extract of Bauhinia variegata Linn (EEBV) for synergistic anthelmintic activity. After drug administration, effect of PG 1 , PG 2 , PG 1 + EEBV (all composition)  and PG 2 + EEBV (all composition) were found to be significant at the level p<0.01 as  compared to Standard and Control group. The synergistic activity of PG with EEBV might be due to tannin which interferes with energy generation in helminth worm by inhibiting oxidative phosphorylation. Effect of tannin might be potentiated in presence of PG. Other possible mechanism might be that presence of PG could potentiate binding of free protein in GIT of host animal and causes death. This work will open new avenue for the study of various preparations used in worship because this study has showed the synergistic anthelmintic activity. Further studies may reveal some more pharmacological activities like antinociceptive, anti-stress etc. This will give impetus for the study of various materials used in worship of God which will reveal the logic of materials used in worship.

Key words: Ethanolic extract of Bauhinia variegata Linn (EEBV), Anthelmintic activity, Panchagavya.