REVIEW ARTICLE: A COMPARATIVE REVIEW ON VARIOUS NON-INVASIVE TECHNIQUES OF INSULIN

ABSTRACT

There is a continuing search for improved insulin formulations in order to imitate as closely as possible the physiological pattern of insulin secretion, and thereby to minimize the complications of diabetes mellitus. This review article covers all the most relevant non-invasive insulin delivery methods under development, respective technology and clinical data available according to their status of development. Great efforts have been made in searching for noninvasive modes of insulin administration that will avoid the need for parenteral administration. These include: oral, colonic, rectal, nasal, ocular, buccal, pulmonary, uterine and transdermal routes of administration.

Key words: Diabetes, Insulin, Modes of Administration, Drug Delivery.