EVALUATION OF ANTIOBESITY ACTIVITY OF SESAMUM INDICUM LINN. IN HIGH FAT DIET INDUCED OBESITY IN RATS

ABSTRACT

In the present study methanolic extract of Sesamum indicum Linn. (MESI) was carried out to investigate to the explore the effect MESI 200 & 400 mg/kg p.o. on energy balance disorders like obesity, Hyperphagia, Hyperglycaemia and Hyperlipidemia. Obesity was induced by administration of hypercaloric diet for 40 days from the observations of study it could be predicted that methanolic extract of Sesamum indicum exerted significant anti obese activity due to its Hypophagic. Hyperglycemic and Hypolipidemic effect in rats fed on high fat diet. The present pharmacological investigation revealed MESI elicted significant decrease body weight, food intake serum levels of glucose, protein, total cholesterol, LDL,VLDL,TG and increased HDL level.

Key words: Sesamum indicum, High fat diet, Body weight, Lipid profile.