EVALUATION OF ANTI-ULCER ACTIVITY OF METHANOLIC EXTRACT OF LEAVES OF TRICHOPUS ZEYLANICUS

ABSTRACT

Trichopus zeylanicus Gaertn is a perennial herb, belongs to the family Trichopodaceae. The plant is reported for varied ethnic medicinal uses. As there is no literature available on anti-ulcer activity of leaves of Trichopus zeylanicus, the present study was taken up to evaluate for anti-ulcer activity of methanolic extract of leaves of Trichopus zeylanicus. The phytochemical study of methanolic extract showed the presence of saponins, alkaloids, flavonoids, steroids, triterpenoids, carbohydrates and proteins. Acute toxicity studies were performed as per OECD guidelines 423. Anti-ulcer activity was evaluated in aspirin induced ulcer model in swiss albino rats in the dose of 200, 300 and 500mg/kg body weight. Ranitidine was used as standard reference. All the tests extracts and standard were administered orally. The study concluded that, the methanolic leaf extract of Trichopus zeylanicus showed significant (p<0.01) anti-ulcer activity in a dose dependent manner. The test extracts showed a significant reduction in the ulcer score, ulcer number and ulcer index in aspirin induced ulcer model in rats.

Key words: Trichopus zeylanicus Gaertn, Anti-ulcer activity, Aspirin, Ranitidine.