EFFECT OF HYPERGLYCEMIA ON OVARIECTOMY INDUCED BONE LOSS

ABSTRACT

Diabetes confers an adverse cardiovascular and osteoporosis risk profile particularly in women after menopause. Fewer studies have offered a rational correlation between these complications in detail. Hence, this study was undertaken to understand the correlation between diabetes and osteoporosis. Female wistar rats were made hyperglycemic using streptozotocin and osteoporotic by performing bilateral ovariectomy. To understand the combined effect, ovariectomized animals were dosed with streptozotocin after the recovery from ovariectomy. Various markers of diabetes and bone loss were studied using hematological and biochemical estimations. Histological analysis was carried out to understand the cellular damage to liver, kidney and bone. Our results showed that hyperglycemia affects bone metabolism, reduces bone formation and promotes bone resorption, leading to net bone loss. It has alarming effect on the markers of bone health like Alkaline Phosphatase and Tartarate resistant Acid Phosphatase. On the other side, we did not find any significant effects of estrogen loss on the markers of diabetes or cardiovascular diseases. Our study provided the insight into the possible effects of hyperglycemia on bone loss and suggested that individuals with hyperglycemia are having rapid bone loss and are more prone to osteoporosis.

Key words: Diabetes, Osteoporosis, Bone.