ANTI-NOCICEPTIVE, ANTI INFLAMMATORY AND ANTIARTHRITIC ACTIVITY OF MARSDENIA TENACISSIMA STEM EXTRACT

The main purpose of the present investigation is to evaluate anti-nociceptive, anti inflammatory and antiarthritic activity of Marsdenia tenacissima stem extract in Wistar albino rats. Analgesic activity was studied in rats using hot plate and acetic acid models. The anti inflammatory activity of Marsdenia tenacissima ethanolic extract (MTEE) was evaluated by using carrageenan induced paw edema and cotton pellet induced granuloma methods. While its anti arthritic activity was investigated by using freud,s adjuvant induced arthritis model. The both doses of MTEE was found to produce significant analgesic activity. The MTEE suppressed the development of paw edema induced by carrageenan in rats and cotton pellet granuloma weight was significantly reduced in animals. The arthritic animals treated with MTEE significantly reduced the arthritic edema in a dose dependant manner .The results of the present study demonstrates that analgesic, anti inflammatory and antiarthritic activity of Marsdenia tenacissima stem extract in experimental animal models.