EVALUATION OF CENTRAL ANALGESIC ACTIVITY OF AQUEOUS EXTRACT OF SEEDS OF MORINGA OLIEFERA IN EXPERIMENTAL ANIMALS

Evaluation of central analgesic activity of aqueous extract of seeds of Moringa oliefera in experimental animals. Albino wistar rats of either sex weighing 150-200g were used. Aqueous extract of Moringa oliefera seeds (AEMO) was prepared with the help of Soxhlet’s apparatus. The analgesic activity was studied using tail immersion method and Eddy’s hot plate method. Statistical analysis was performed using One-way analysis of variance (ANOVA) followed by post hoc dunnett’s test. P < 0.05 was considered statistically significant. In Tail immersion test all the groups treated with AEMO demonstrated dose dependent increase in reaction time but in AEMO 500 mg/kg and 750mg/kg treated groups there was significant increase in the reaction time when compared to control group (p<0.001) Similarly in Eddy’s hot plate method, AEMO treated groups at the dose of 500mg/kg and 750mg/kg demonstrated dose dependent significant increase in reaction time when compared to control group (p<0.001). Thus it can be concluded from our study that the aqueous extract of Moringa oleifera seeds possesses central analgesic activity.