EVALUATION OF THE ANTIULCER ACTIVITY OF LYOPHILIZED POWDER OF CYNODON DACTYLON IN PYLORIC LIGATION INDUCED GASTRIC ULCERS IN MALE ALBINO RATS

Evaluation of antiulcer effect of Cynodon dactylon was done in pyloric ligation induced gastric ulcers in rats. Animals were divided into 3 groups with 8 animals in each. After making an abdominal incision pyloric ligation was done. One hour before the procedure, normal saline, famotidine, and solution of lyophilized powder of Cynodon dactylon were administered orally to Group I, Group II, Group III and respectively. Animals were sacrificed 22 hours after pyloric ligation. Stomach was cut opened. Contents of the stomach were drained into a graduated centrifuge tube. Parameters observed are: Ulcer index, volume, pH, and free & total acidity of gastric juice. In this study Cynodon dactylon produced a significant reduction in the mean ulcer number, ulcer index & volume of gastric acid secretion, whereas reduction in mean ulcer size, free & total acidity were not statistically significant Results of the study indicate that Cynodon dactylon has antiulcer effect.