COMPARATIVE STUDIES ON ANALGESIC POTENTIALS OF PREMNA TOMENTOSA WILLD AND PREMNA LATIFOLIA ROXB. USING DIFFERENT MODELS

The comparative studies on analgesic potentials of whole plants methanol extract of Premna tomentosa Willd (MEPT) and Premna latifolia Roxb. (MEPL) using Formalin induced pain model and Hot plate reaction time in mice. Standard drugs such as indomethacin and morphine used in above methods. The results showed dose-dependent and significant (P < 0.01) increases in pain threshold at 30 min post-treatment with doses of 200 and 400 mg/kg of MEPT and MEPL in Formalin induced pain model and Hot plate reaction time in mice. The MEPT and MEPL (200 and 400 mg/kg) exhibited a dose-dependent inhibition of hot plate reaction time with centrally acting analgesic effect and also showed a significant (P < 0.01) inhibition in both phases of the formalin pain test, but with a less intense effect in the first phase with peripherally mediated analgesic effect. The results indicate that the analgesic potency of Premna tomentosa Willd and Premna latifolia Roxb. is both centrally and peripherally mediated. Premna latifolia Roxb. extract showed more potent analgesic activity in above models than Premna tomentosa Willd extract.