ISOLATION, ESTIMATION AND CHARECTERIZATION OF STARCH FROM SEEDS OF ARTOCARPUS HETEROPHYLLUS

A study has been carried out to investigate the binding and disintegrating properties of modified starch, isolated for m the fresh seeds of “Artocarpus heterophyllus“belonging to the family “Moraceae”. After modifications of Artocarpus starch (MAS) dissolution profiles were studied. Paracetamol (500mg) was used as marker drug and dissolution data of MAS compared with explotab (marketed modified rice starch) (ES) and rice starch (PS) in batches of 200. All the products met the requirement of in vitro parameters like uniformity of weight, assay, friability, and hardness as per pharmacopoeial requirements. These products also confirm the dissolution specification of USP. The amount of modified Artocarpus starch (MAS) required as binding and disintegrating agent was three fourth of the amount maize and rice starch. Therefore modified Artocarpus starch can be effectively used in tablet technology.