NOVEL DIOSCOREA OPPOSTIFOLIA TABLETS AND ITS ANTI DIABETIC POTENTIAL AGAINST STREPTOZOTOCIN-INDUCED DIABETIC RATS

Present study focused on development of herbal tablets using Dioscorea oppostifolia pure compounds and evaluate the anti diabetic activity of Dioscorea oppostifolia tablet formulation using streptozotocin induced diabetic rats. Isolate the pure compounds from Dioscorea oppostifolia root using column chromatography. Pure compounds were used for herbal tablet formulation by direct compression method and performed quality control tests. Developed formulation was used to evaluate anti diabetic activity on streptozotocin and alloxan-induced diabetic rats. Stigmasterol and ursolic acid were isolated from the roots of Dioscorea oppostifolia and confirmed by analytical data. Developed herbal tablet formulation was found in an acceptable range of thickness, hardness, weight variation and friability. DSC study revealed stability of the drug in the presence of excipients. Dioscorea oppostifolia tablet showed significant decrease in blood glucose and improved antioxidant activity on diabetic rats. Anti diabetic activity of tablet formulation due to the sterol and triterpenoid nature of Stigmasterol, Ursolic acid. Developed Dioscorea oppostifolia tablets exhibited unique anti-diabetic activity against streptozotocin and alloxan induced diabetic rats