SCRENING OF PHYTOCHEMICAL AND INVITRO ANTIDIABETIC ACTIVITY OF METHONALIC FRUIT EXTRACT OF Abutilon Indicum

Diabetes is a group of chronic metabolic disorder characterised by high blood sugar levels over a prolonged period of time. One of the approaches is to reduce production and absorption of glucose from gastrointestinal tract through the inhibition of carbohydrate digesting enzymes such as alpha amylase and alpha glucosidase .In the present study the methanoic fruit extracts of Abutilon indicum was screened for alpha (?)-amylase inhibition using an in vitro model. The plant extracts were also examined for its antioxidant activities, reducing power capacity, estimation of total phenolic content, flavonoid content and flavonol content. The study revealed that the different concentrations of the methanolic fruit extract possessed a very good amount of total phenolics, flavonoid and flavonol and exhibit anti oxidant activity. The methanolicfriut extract exhibited significant ?-amylase inhibitory activity with an IC50 value 225.54 3.537?g/ml and well compared with standard acarbose drug 213.27± 2.758. Thus, it could be concluded that due the presence of antioxidant components the plant extract have well prospective for the management of hyperglycemia, diabetes and the related condition of oxidative stress.