HERBAL MICROSPHERES OF CROSSANDRA INFUNDIBULIFORMIS L FOR ENHANCED ANTIULCER ACTIVITY

Herbal medicines have been shown to be less expensive and safer than synthetic pharmaceuticals in the treatment of many ailments, although they are less effective and not targeted. As a result, using novel drug delivery methods to administer herbal extracts can significantly improve their release, potency, and activity. Crossandra infundibuliformis L. leaves methanol extract had been combined into mucoadhesive microspheres. Sodium alginate, carbopol 934, and sodium CMC were used to make mucoadhesive microspheres (carboxy methyl cellulose). The produced microspheres were tested for physical and physicochemical characteristics, invitro release, and invivo antiulcer efficacy in Wistar albino rats with ethanol-induced ulceration. When compared to extract delivered directly, the produced microspheres demonstrated comparable physicochemical characteristics, prolonged release for up to 8 hours, and enhanced antiulcer efficacy. After adequate chemical and biological standardisation, herbal extracts can be given utilising new drug delivery methods