2D-QSAR ANALYSIS: DESIGN DEVELOPMENT AND EVALUATION OF BETA-CARBOLINE ANALOGUES

The best model designed exposed that the Log P values and Charge-Dipole energy of the molecules are positively associated to the biological activity whereas the Bending energy values showed negative relationship. The best model developed also shows a greater control of Log P values and Charge-Dipole energy on biological activity than bending energy. Therefore, one should keep in mind that only those groups which impart the above mentioned changes must be attached to the molecules for escalating the biological activity. This study may prove to be helpful in further studies related with the synthesis of newer potent derivatives of ?-carboline.