ANTI-DIABETIC ACTIVITY OF SMILAX CHINENSIS L. EXTRACT IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

ABSTRACT 

In Indian traditional system of medicine, Smilax chinensis L. (Liliaceae) is prescribed for the treatment of diabetes mellitus. In the present study, the antidiabetic effect of methanol extract of Smilax chinensis L. leaves (MESC) was investigated in streptozotocin (STZ)-induced diabetic rats. Albino wistar rats were rendered diabetic by STZ (55 mg/kg, intraperitoneally). MESC was orally administered to STZ-induced diabetic rats at 200 and 400 mg/kg, p.o doses for 14 days to determine anti-diabetic activity. The fasting blood sugar levels and serum biochemical analysis in STZ-induced diabetic rats were investigated. Oral administration of MESC (200 & 400 mg/kg) for 14 days exhibited a significant reduction in serum glucose, total cholesterol, and triglycerides in alloxan diabetic rats. The anti-diabetic activity of the methanol extract of Smilax chinensis L.(MESC) were similar to those produced by glibenclamide at 600µg/kg (positive control, p < 0.01). The results demonstrate that MESC <a href="http://www.aucheaptrx.com/">cheap trx for sale</a>  possesses potent anti-diabetic activity in STZ-induced diabetic rats. These very encouraging results for diabetes control by methanol extract of Smilax chinensis L. make the need for clinical studies in humans evident.

Keywords: Smilax chinensis L., STZ-induced diabetic rats, anti-diabetic, LDL, VLDL, TG, Total cholestrol.