STUDIES ON PHYTOCHEMICAL AND ANTICONVULSANT PROPERTY OF MARTYNIYA ANNUA LINN.

Abstract:

         The present report is an investigation of anti seizure activity of Martynia annua Linn. is a well known plant which is being used in Indian traditional medicines for epilepsy, inflammation and tuberculosis. The methanolic extract of Martynia annua Linn. (MEMA) was subjected to acute toxicity and then screened for anticonvulsant activity on Maximal Electroshock (MES) and Pentylenetetrazole (PTZ) induced seizures models in albino wistar rats. Acute toxicity of extract was non toxic up to the recommended dose 2000 mg/kg body weight orally as per OECD guidelines No. 423. Animals were treated with MEMA at doses of 200 and 400 mg/kg body weight. These studies showed, the mean duration <a href="http://www.aucheaptrx.com/">cheap trx for sale</a>  of extensor phase of test group reduced to significant level as compared to control group. In Pentylenetetrazol induced seizure test, onset of myoclonic spasm and clonic convulsion was delayed in the test group. MEMA showed anticonvulsant activity against MES and PTZ animal models. However, further studies still needed to be carried on exposure of the extract to humans. 

Keywords: Anti seizure activity, Martynia annua Linn., Maximal Electroshock (MES) , Pentylenetetrazole (PTZ).