ANTI-MITOTIC ACTIVITY OF EMBELIN DERIVATIVES

ABSTRACT

Identifying the active chemical ingredients of ancient medicines and the molecular targets of those ingredients is an attractive therapeutic objective. Embelin is isolated from berries of embelia ribes using hexane and crystallized from benzene. Series of Embelin derivatives, 2-hydroxy-5-substituted-3-undecylcyclohexa-2,5-diene-1,4-diones (IIa-f) were synthesized from Embelin by treating alkyl and aryl halides in dichloromethane, sodium hydroxide and tetrabutyl ammonium bromide to give respective ethers. The title compounds evaluated for antimitotic activity, using germinating Bengal gram seeds and germinating Onions, Allium cepa. New Embelin derivatives demonstrated antimitotic activity <a href="http://www.aucheaptrx.com/">cheap trx for sale</a>   in the order of IIf, IIa, IIb, IIe, IId, IIc. Among all the derivatives of Embelin, benzyl derivative (IIf) has shown significant activity when compared to rest of the compounds.

Key Words: Antimitotic activity, Embelin