ANTICANCER AND ANTIMICROBIAL ACTIVITY OF 1-[(5-SUBSTITUTED-1,3,4 OXADIAZOL-2-YL) METHYL]-4-BENZYLPIPERAZINES

ABSTRACT

The synthesis of 1-[(5-sustituted-1,3,4-oxadiazol-2-yl) methyl]-4-benzylpiperazines VIa-j was carried out by refluxing the 1-benzylpiperazine II with ethylchloroacetate III in dry acetone in the presence of potassium carbonate and subsequent hydrazinolysis with hydrazine hydrate. Finally 2-(4-benzylpiperazin-1-yl)aceto- hydrazide V was treated with appropriate carboxylic acids in the presence of phosphorous oxy chloride to produce title compounds. All the title compounds (VIa-j) were screened for anticancer activity using HBL-100 cell lines by MTT method and antibacterial activity against B. subtiliis, S.aureus, E.coli and P.vulgaris.The structures of newly synthesized compounds were established on the basis of elemental analysis, IR, ¹H NMR and mass spectral data.

Keywords:- Anticancer, antimicrobial, antifungal, piperazine and oxadiazole.